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Stratification by baseline nutritional status (e.g., selenium or iodine repletion) would clarify which populations benefit most

Mol Breed 9:93101 Vernoux T, Wilson RC, Seeley KA, Reichheld JP, Muroy S, Brown S, Maughan SC, Cobbett CS, Van Montagu M, Inze D (2000) The ROOT MERISTEMLESS1 / CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenace of cell division during postembryonic root development

And indeed, the frequency of B12 injections is guided by symptoms, not by irrelevant blood measurements of B12, methylmalonic acid or any other biomarker

Advise patients that because imiquimod activates the immune system locally, inflammation is an expected result which indicates that the cream is likely to be effective